Can you take Dramamine with diphenhydrAMINE? Using diphenhydrAMINE together with dimenhyDRINATE may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. What is the best over the counter medicine for seasickness? Over-the-counter drugs used to deter and/or treat mal de mer include Dramamine, Meclizine (common name Bonine) or diphenhydramine (commonly known as Benadryl). On some ships these are dispensed freely. They are also sold in the sundries shop. Is Dramamine an antihistamine? Dramamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Dramamine is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness. Dramamine may also be used for purposes not listed in this medication guide.