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How long after taking Valtrex does it work? For most initial herpes outbreaks and cases of recurring herpes, valacyclovir takes effect very quickly and provides some level of relief in as little as two to three days. Generally, the sooner you take valacyclovir after noticing symptoms, the faster it will be to provide relief.
Is Valtrex toxic? As a prodrug of acyclovir, similar toxicity is expected in overdose. Manifestations of acyclovir toxicity include acute renal insufficiency, lethargy, coma, agitation, myoclonus and in severe cases seizures. 2) MILD TO MODERATE TOXICITY : Nausea, vomiting, diarrhea and constipation may develop.